When I had my Vista laptop, I used AVG antivirus (free version), Spywareblaster, Spybot Search and Destroy, and Ad-Aware. Many of the apps may not have been necessary. I had the computer for a year and never had an infection of any kind ... Well, at least not one that could be detected by the programs.
Right now I have a Macbook so I just have Clamxav which I use to scan things I might download from the internet. That's it.
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